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Biochemistry General 1198763b

Unaltered final product of TCA cycle ?

A
Oxaloacetate
B
Acetyl CoA
C
CO2
D
Pyrovate
High-Yield Explanation
TCA cycle consists of sequential reactions. It begins with condensation of four carbon oxaloacetate molecule with 2 carbon acetyl CoA molecule to form six carbon citrate molecule. In subsequent reaction two carbon atoms are lost in the form of CO2 at two different reactions. A series of modifications occur in the remaining four carbon atoms to ultimately form oxaloacetate. Thus the last substrate (oxaloacetate) of one cycle is ready for use as a substrate in the next cycle. In this way, there is no net generation of OAA, or of any of the cycle intermediates.

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