Screening by using maternal serum alpha fetoproteins helps to detect all of the following except:
High-Yield Explanation
Elevated Levels
Error in dates
Multifetal pregnancy
Severe oligohydramnios
Neural tube defects
Pilonidal cysts
Esophageal or intestinal obstruction (and atresia)
Liver necrosis
Cystic hygroma
Sacrococcygeal teratoma
Fetal death
Abdominal wall defects:
– omphalocele
– gastroschisis
Urinary obstruction
Renal anomalies:
– polycystic kidney
– absent kidneys
Congenital nephrosis
Osteogenesis imperfecta
Congenital skin defects
Cloacal exstrophy
Chorioangioma of placenta
Low birth weight
Placental abruption
Placenta accreta
Preeclampsia
Improper adjustment for low maternal weight
Maternal hepatoma or teratoma
Low Levels
G: Gestational trophoblastic diseases
O2: Overestimated gestational age, overweight mother
A: Spontaneous abortion
T: Trisomy (21 or 18)