A 40-year-old man develops erythema nodosum, conjunctivitis, and a pleural effusion. Over several weeks, pulmonary lesions lead to cavitation and a large, thin-walled cavity. He was traveling in Arizona before becoming ill. Sputum samples reveal mature spherules. Which of the following is the most likely diagnosis?
High-Yield Explanation
Coccidioidomycosis may present with a syndrome of erythema nodosum, fever, and conjunctivitis. Serious complications include cavitating lung lesions or meningitis.