In Ochronosis there is deficiency of which of the following enzymes?
High-Yield Explanation
The defective enzyme in Ochronosis (Alkaptonuria) is homogentisic acid oxidase in tyrosine metabolism. Homogentisate gets oxidised by polyphenol oxidase to benzoquinone acetate which undergoes polymerization to form a pigment ALKAPTON. Alkapton gets deposited in connective tissues, bones and various organs resulting in condition called OCHRONOSIS.