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Pharmacology General 10c7d1aa

Enalapril increases the level of:

A
Interferon
B
Growth factors
C
Bradykinin
D
All of the above
High-Yield Explanation
Enalapril is an ACE inhibitor and the adverse effect profile of all ACE inhibitors is similar. One side effect is cough in the patients taking ACE inhibitor. A persistent brassy cough occurs  in 10- 16% patients within 1- 8  weeks, often requires discontinuation of the drug-subsides 4- 6 days thereafter. It is not dose related and appears to be  caused by inhibition of bradykinin/substance P breakdown (which leads to increase in levels of Bradykinin)  in the lungs of susceptible individuals. Reference: Essentials of Medical Pharmacology Eighth Edition KD  TRIPATHI  page no 531

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