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Pharmacology Pharmacokinetics 1090685c

Prodrug of cetrizine is -

A
Foxefenadone
B
Terfenadine
C
Hydroxyzine
D
Azelastine
High-Yield Explanation
Ans. is 'c' i.e., Hydroxyzine o Cetrizine is a metabolite of Hydroxyzine with marked affinity for peripheral H1 receptors; penetrates brain poorly,o It inhibits release of histamine and of cytotoxic mediators from platelets as well as eosinophil chemotaxis during secondary phase of allergic response.o It is indicated in upper respiratory allergies, pollinosis, urticaria and atopic dermatitis; also used as adjuvant in seasonal asthama.

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