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Pharmacology Central Nervous system 1040843f

Which of the following antiepileptic agents acts on the GABAergic system to decrease the uptake of GABA into neurons and glial cells?

A
Vigabatrin
B
Progabide
C
Gabapentin
D
Tiagabine
High-Yield Explanation
It potentiates GABA mediated neuronal inhibition by depressing GABA transpoer GAT 1 which removes synaptically released GABA into neurons and glial cells REF: KD TRIPATHI 8TH ED. page 421

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