Brinzolamide is a?

Ans. is 'c' i.e., Noncompetitive reversible inhibitor Brinzolamide is a white powder formulated as l% ophthalmic suspension to reduce intraocular pressure.Pharmacologically Brinzolamide is a highly specific noncompetitive reversible and effective inhibitor of carbonic anhydrase II (CA-II) which is able to suppress formation of aqueous humour in the eye.Carbonic anhydrase catalyzes the reversible reaction of water and carbon di-oxide to form negatively charged bicarbonate ions.In human tissues there are 7 different isoenzymatic forms of carbonic anhydrase, pancreas, eyes, central nervous system and lungs.In the eye the enzyme is expressed mainly in the ciliary processes of the ciliary body.The main ocular effect of Brinzolamide.Brinzolamide suppresses the formation of aqueous humour in the ciliary body and thus decrease intraocular pressure.In the ciliary epithelium the inhibition of carbonic anhydrase slows the formation of bicarbonate ions and their secretion into the posterior chamber of the eye.This reduces the sodium transport into the posterior chamber and decrease aqueous humour production resulting in lower intraocular pressure.Brinzolamide is used in ocular hypertension and primary oven angle glaucoma.Intraocular pressure reduction is fundamental in primary open angle glaucoma or in ocular hypertension to delay the onset or prevent the onset of primary open angle glaucoma in ocular hypertension or the progression of damage in primary open angle glaucoma.