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Biochemistry General 0fb6ab11

The major source of NADPH for fatty acidsynthesis ?

A
PPP
B
TCA cycle
C
Glycolysis
D
Glycogenolysis
High-Yield Explanation
Ans. is 'a' i.e., PPP Source of NADPH for lipogenesis NADPH is involved as donor of reducing equivalentse in both the reduction of 3-ketoacyl by 3 ketoacyl reductase and of 2,3- unsasturated acyl by enoyl reductase. The main source of NADPH for lipogenesis is the pentose phosphate pathway: PPP (Hexose monophosphate shunt: HMP shunt)deg. Other sources of NADPH include:- The reaction that conves malate to pyruvate catalyzed by malic enzyme. Exramitrochondrial isocitrate dehydrogenase.

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