Stimulation of which brain area can modulate the sensation of pain?
High-Yield Explanation
Endogenous analgesic system
periaqueductal gray (PAG)-projects to nucleus raphé magnus and rostral ventromedial medulla
project to the dorsal horn of the spinal cord- release serotonin and norepinephrine
Locus coerulus-Nor epinephrine
Stress induced analgesia:
release of endogenous cannabinoids such as 2-arachidonoylglycerol (2AG) and anandamide acts on CB1(Euphoria) and CB 2 (Pain)receptors