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Pharmacology Anaesthesia 0ef07b5a

All of the following are propeies of local anesthetics EXCEPT:

A
Blockade of voltage dependent Na+ channels
B
Preferential binding to resting channels
C
Slowing of axonal impulse conduction
D
Increase in the membrane refractory period
High-Yield Explanation
- Local anesthetic receptor is located within the channel in its intracellular half. - LA traverses the membrane in unionized form. - LAs act from within the neuron and are more active when the neuron is rapidly firing (i.e., Na+ channels are open). so it doesnot act in resting form.

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