Most dangerous Osteogenesis Imperfecta (OI) in utero foetus

(C) Type 3 OI# Osteogenesis Imperfecta (OI): 4 different genes responsible for collagen production, and any combination, or all, of them can be affected. These combinations produce eight types of brittle bone disease, labeled as type 1 OI through type 8 OI. The first four types are the most common. Last 4 types are extremely rare and most are subtypes of type 4 OI.> Type 1 OI is the mildest and most common form of brittle bone disease your baby can have. With this type, your child's body produces normal quality collagen, but just not enough of it.> Type 2 OV, the most severe form of brittle bone disease, is fatal. In type 2 OI, your child's body either produces poor-quality collagen or not enough of it. Type 2 OV can produce bone deformities.> Type 3 OI is a severe form of brittle bone disease that also causes bones to break easily. In Type 3 OI, your child's body procuces enough collagen, but it is of poor quality. A baby's bones can even begin to break before birth.> Type 4 OI is the most variable form of brittle bone disease because its symptoms range from mild to severe