Which of the following of drugs is not recommended in septic shock

Initial management of hypotension is the administration of iv fluids - normal salineAdrenal insufficiency is strongly suspected in septic patients with refractory hypotension and hydrocoisone may be given Recombinant activated protein C (aPC) was the 1st drug to be approved by FDA for the treatment of patients with severe sepsis or septic shock(ref: Harrison's 18/e p 2223, 17/e p1699-1701)