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Pathology General 0ea2c253

Hemophilia A has following except -

A
↓ VIII factor
B
↑PTT
C
↑PT
D
Normal BT
High-Yield Explanation
Hemophila A Hemophilia A is due to deficiency of factor VIII. Hemophilia A is inherited as an X-linked recessive trait. Factor VIII is an intrinsic pathway component required for activation of factor X. Clinical manifestations are due to defect in coagulation system : - Large post-traumatic ecchymoses or hematoma. Prolonged bleeding after a laceration or any form of surgical procedure. Bleeding into weight-bearing joints. Petechiae are characteristically absent (in contrast to platelet dysfunction where bleeding occurs from small vessels of the skin and mucous membrane, e.g., petechiae). Laboratory findings ↑ PTT Normal PT Normal BT Normal platelet counts Remember Hemophilia B (Christmas disease) is due to deficiency of factor IX. Hemophilia B has clinical features and laboratory findings similar to hemophilia A.

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