A 28-year-old woman presents with a recent episode of coughing up some blood, frequent nosebleeds, and now decreased urine output. A nasal mucosa ulcer was seen on inspection. Her urinalysis is positive for protein and red cells consistent with a GN. The CXR shows two cavitary lesions and her serology is positive for antineutrophil cytoplasmic antibodies (ANCA). Which of the following is the most likely diagnosis?
High-Yield Explanation
Numerous diseases are associated with renal and pulmonary manifestations, including lupus, Goodpasture's syndrome, and Wegener's granulomatosis. Wegener's is typically associated with antineutrophil cytoplasmic antibodies.