Which of the following does not cross blood brain barrier

Refer katzung 11e p 121 Pralidoxime or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to treat organophosphate poisoning in conjunction with atropine and diazepam Pralidoxime is a quaternary charged oxime that can bind to inactivated ChE and reactivate its functional activity (Fig. ... However, because of the highly charged nature of 2-PAM, it has a poor ability to cross the blood brain barrier (BBB)