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Gynaecology & Obstetrics Medical Illness Complicating Pregnancy 0e548674

A pregnant woman developed idiopathic cholestatic jaundice. The following condition is not associated:

A
Intense itching
B
SGOT, SGPT less than 60 IU
C
Serum bilirubin > 5mg/dl
D
Markedly |ed levels of alkaline phosphatase
High-Yield Explanation
Intrahepatic Cholestasis of Pregnancy Onset - Third trimester Present with pruritis, icterus or both Lab findings : Sr. bilirubin level <5 mg/dL With minimal or no elevation in transaminases. Alkaline phosophatase levels are elevated. Histopathology: Mild cholestasis with bile plugs in the hepatocytes of the centrilobular regions. Treatment Ursodeoxycholic acid & Cholestyramine acid are used for pruritis

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