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Physiology General 0e20761b

A 32-year-old high altitude mountaineer is observed to have a hematocrit of 70 percent. Which of the following represents the most likely cause/explanation

A
Polycythemia with increased red cell mass
B
Relative Polycythemia due to dehydration
C
Polycythemia due to hemoconcentration
D
Polycythemia with high altitude pulmonary edema
High-Yield Explanation
At high altitude, there can be acute changes and changes due to acclimatization. Acute mountain sickness Dyspnoea, dizziness, tiredness, tachycardia, palpitation, nausea, vomiting etc. At higher altitudes- pulmonary oedema and cerebral oedema may occur. Acclimatization changes Hyperventilation leading to respiratory alkalosis Increased 2,3DPG- Hb-O2 dissociation curve shifts to right. Increased erythropoietin leading to absolute polycythemia with increased red cell mass. Increased renal excretion of bicarbonate Increased tissue vascularity Increased oxidative metabolism Increased diffusion capacity of the lung​ Increased myoglobin

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