A 32-year-old high altitude mountaineer is observed to have a hematocrit of 70 percent. Which of the following represents the most likely cause/explanation
High-Yield Explanation
At high altitude, there can be acute changes and changes due to acclimatization.
Acute mountain sickness
Dyspnoea, dizziness, tiredness, tachycardia, palpitation, nausea, vomiting etc.
At higher altitudes- pulmonary oedema and cerebral oedema may occur.
Acclimatization changes
Hyperventilation leading to respiratory alkalosis
Increased 2,3DPG- Hb-O2 dissociation curve shifts to right.
Increased erythropoietin leading to absolute polycythemia with increased red cell mass.
Increased renal excretion of bicarbonate
Increased tissue vascularity
Increased oxidative metabolism
Increased diffusion capacity of the lung
Increased myoglobin