Kaposi sarcoma is commonly seen in -

• DFSP is a low-grade sarcoma because it may recur locally but rarely metastasizes. • Monomorphous, mononuclear, spindle cell lesion involving both dermis and subcutis. • MC site: Trunk (50%) >Extremities (30%) >Head and neck (20%) Pathology • Large lesions often are associated with satellite nodules; Positive for CD34 • Have unpredictable radial extensions of tumor permeating through the subcutaneous tissue large distances from the primary nodule. • More than 75% of DFSP have a ring chromosome, composed of translocated portions of chromosomes 17 and 22 Clinical Features • Typically presents in early or mid-adult life, beginning as a nodular cutaneous mass. • Pattern of growth: Slow and persistent • Lesion enlarges over many years, it becomes protuberant Treatment • Aggressive resection with special attention to radial margins (local recurrence rate <5%) • Up to 50% recur after simple excision. • Imatinib: First line of treatment for advanced disease.