Biochemistry General 0ceda75e How does hyperammonemia inhibit TCA cycle A By depleting Alpha Ketoglutarate B By depleting Oxaloautate C By increasing concentration of alpha ketoglutarate D By increasing concentration of oxaloautate. High-Yield Explanation Build up of cummonemia which occurs in area cycle disorders or advanced liver disease inhibits TCA cycle by depleting Alpha ketoglutarate.