Pediatrics C.V.S. 0ce1c206 Indomethacin causes: A Closure of ductus in premature neonate B Patent ductus arteriosus C Closure of ductus in term & premature neonates D Closure of ductus in older children also High-Yield Explanation a. Closure of ductus in premature neonate(Ref: Nelson's 20/e p 2197)Indomethacin, a Prostaglandin inhibitor is used in medical closure of Ductus arteriosus in preterm neonates with PDA.