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Pharmacology C.N.S 0c2c5201

Maximum extrapyramidal side-effect is seen with:

A
Haloperidol
B
Chlorpromazine
C
Imipramine
D
Clomipramine
High-Yield Explanation
Ans. A. HaloperidolTypical antipsychotic drugs are known to cause extrapyramidal side effects. They block D2 receptors. They are of two types: high potency and low potency. High potency drugs like haloperidol are known to cause maximum EPS. Low potency drugs like chlorpromazine have alpha blocking properties and show anticholinergic side effects.

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