Cryosurgery is effective in all except:

Cryosurgery This is a procedure whereby destruction of the tissue is effective by freezing. Indications • Cervical ectopy • Benign cervical lesions—such as CIN (ideal for minor degree and localized CIN), condyloma acuminata, leukoplakia, etc. • Condyloma acuminata of vulva and VIN diagnosed colposcopically and not more than 2 cm in size. • VAIN, condyloma acuminata or vault granulation tissue following hysterectomy. • As a palliative measure to arrest bleeding in carcinoma cervix or large fungating recurrent vulvar carcinoma. Principle: It consists of a ‘probe’, the tip of which is cooled to a temperature below freezing point (– 60°C). Freezing produces cellular dehydration by crystallization of intracellular water and ultimately death of cells. This is effective by rapid expansion of gas which is passed through it. Carbon dioxide is widely used while nitrous oxide and liquid nitrogen are also used. The application to the cervix freezes the tissue to a depth of about 3 mm. Healing is complete in 6 to 10 weeks.