Hyperbilirubinemia in a child can be due to

Breast milk jaundice - bilirubin in excess of 10mg/dl. Seen beyond 3rd-4th weeks of life. A diagnosis of breast milk jaundice should be considered if this is unconjugated (not staining nappies) and other causes for prolongation such as inadequate feeding, continuing hemolysis, extravasated blood, G6PD deficiency and hypothyroidism have been ruled out. Cystic fibrosis is an autosomal recessive disorder caused by mutation in the gene encoding the chloride conductance channel, CF transmembrane conductance regulator(CFTR). The failure of chloride conductance by epithelial cells leads to dehydration of secretions that are too viscid and difficult to clear. Fanconi syndrome is characterised by tubular proteinuria and aminoaciduria and variable degrees of bicarbonaturia, phosphaturia, electrolyte wasting and glucosuria. Alpha1-antitrypsin deficiency (AATD) is a genetic inherited autosomal-codominant condition. People with AATD are predisposed to obstructive pulmonary disease and liver disease (eg, cirrhosis and hepatocellular carcinoma in children and adults). Reference : page 172,499, 393 Ghai Essential Pediatrics 8th edition