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Pathology Autoimmune Diseases 0bd8e970

To rule out rheumatoid arthrirtis, most important among the followings is?

A
HLA DR8
B
HLA DR4
C
HLA DQ1
D
HLA B27
High-Yield Explanation
Ans. is 'b' i.e., HLA-DR4 o DR4 is strongly associated with RA(also with Type 1 DM Pemphigus vulgaris).Other optionso HLA-B27 is associated with seronegative spondyloartropathies (ankylosing spondylitis, Psoriatic arthritis, Reiter's syndrome, reactive arthritis) and acute anterior uveitis o HLA DR8 is associated with Type 1 DM.o HLA DQ1 is associated with pemphigus vulgaris.

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