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Pathology Haematology 0b3f0549

Intrinsic cell wall defect of RBCs is feature of -

A
Paroxysmal nocturnal hemoglobinuria
B
Sickle cell anemia
C
Hemophilia
D
All of the above
High-Yield Explanation
Paroxysmal nocturnal hemoglobinuria is a disease that results from acquired mutations in the phosphatidylinositol glycan complementation group A gene (PIGA), an enzyme that is essential for the synthesis of ceain membrane associated complement regulatory proteins. Ref :Robbins pathologic basis of disease ; south east asia edition ;pg:642

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