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Pathology General 0b07dc7f

In Wegener's glomerulonephritis, the characteristic features seen is:

A
Focal necrotizing glomerulonephritis
B
Granulomas in the vessels wall
C
Interstitial granulomas
D
Nodular glomerulosclerosis
High-Yield Explanation
Ans:B.)Granulomas in the vessels wall Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a rare multisystem autoimmune disease of unknown etiology. Its hallmark features include necrotizing granulomatous inflammation and pauci-immune vasculitis in small- and medium-sized blood vessels. Cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) directed against PR3 is most specific for GPA.

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