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Microbiology Virology (RNA Virus Pa-1,2 & Miscellaneous Viruses) 0ac36468

All of the following is/are true about Rubella in pregnancy except

A
Diagnosed when IgM antibodies are present in the neonatal serum
B
Diagnosed when IgG antibodies persist for more than 6 months
C
Most common defects are cataracts, deafness and hea defects
D
Maternal infection after 16 weeks of gestation result in major congenital defects
High-Yield Explanation
Maternal infection after 16 weeks of gestation result in major congenital defects is not true. Timing of fetal infection determines the extent of teratogenic effect in fetus: Ist 2 months Abnormalities in 65-85% cases, Multiple congenital defects (cataracts, deafness and hea defects) Spontaneous aboion 3rd month of fetal life: 30% to 35% chance of developing a single defect, Deafness ,CHD. During the 4th month 10% risk for a single congenital defect Beyond the 4th month No risk to fetus The classic triad of congenital Rubella includes - Deafness Cataract Congenital hea disease (PDA and PS)

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