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Pharmacology Bromocriptine 0a3f92ca

Prolactin secretion is inhibited by:

A
Dopamine antagonist
B
GABA
C
Neurophysin
D
Bromocripitine
High-Yield Explanation
Ans. is 'd' i.e. BromocriptineRef. K.D.T. 4th/ep244, K.D.T 5th/ep217Prolactin is under predominant inhibitory control of hypothalamus through prolactin releasing inhibitory hormone (PRIH).PRIH is a dopamine that acts on pituitary lactotrope D2 receptor.So, Dopaminergic agonists decrease plasma prolactin levels. These agonists are :Dopamine*Bromocriptine*Apomorphine*Dopaminergic antagonists and DA depletes will increase prolactin levelDopaminergic antagonists are :ChlorpromazineHaloperidolMetoclopramideDopamine depletes are :Reserpine Methyl dopaUses of Bromocriptine are :Hyperprolactinemia*AcromegalyParkinsonism Hepatic comaSuppression of lactation and breast engorgement after delivery.

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