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Biochemistry Enzyme basics and serine proteases 09eac0bd

All of the following statements about enzymes are true EXCEPT:

A
Multienzyme complexes greatly reduce the rates of reactions
B
Isoenzymes differ in their amino acid sequence
C
Allosteric regulators do not bind to the active site of the enzyme
D
Translational regulation is method of long term regulation of enzymatic activity
High-Yield Explanation
Isoenzymes are different enzymes catalysing the same chemical reaction - option b is correct. Allosteric regulators bind to a site other than the active site - option c is correct. Translational regulation means inhibiting/activating the synthesis of enzyme/protein (protein translation) to stop/increase the reaction. It takes time and hence is a long term regulation method. - option d is also correct. On the other hand allosteric regulation work instantaneously. Multienzyme complexes greatly increase the rate of reactions. So, option a is wrong statement. It is impoant to differentiate multifunctional enzyme and multienzyme complex. Multifunctional Enzyme Multi enzyme complex Enzymes that contain more than one enzymatic activity (active site) within a single polypeptide chain. Stable, non-valent assembly of different enzymes involved in consecutive reactions of a metabolic pathway. e.g. Fatty acid synthase e.g. PDH complex

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