Most common joint involved in gout is -

Ans. is 'c' i.e., MP joint of great toe {Ref: Harrison 17th/ep. 2165, 2166]o Gout is the common end point of a group of disorders that produce hyperuricemia.o It is marked by transient attacks of acute arthritis intitiated by crystallization of monosodium urate into the joints, leading eventually to chronic gouty arthritis and deposition of masses of urates in joints and other sites, creating tophi.o Most common joint involved in gout is big toe, i.e. metatarsophalangeal joint of great toe.o Tophi are pathognomic of gout. They are formed by large aggregations of urate crystals. The urate crystals are surrounded by -a) Macrophagesb) Lymphocytesc) Large foreign body giant cellso They are seen in the-a) Articular cartilages of jointsb) Periarticular ligamentsc) Tendons and soft tissuesd)Achilles tendone) Ear lobesf) Synovial fluido Less common sites of involvement are -a) Kidneyb) Nasal cartilagec) Skin of the finger tips, palms or soles.