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Pediatrics Metabolic disorders 09617b61

True about wilson&;s disease

A
Increase in urinary copper and increased serum ceruloplasmin and copper
B
Increased serum ceruloplasmin levels with increased urinary copper
C
Elevated hepatic copper level and increased serum ceruloplasmin levels
D
Increased in urinary copper and decreased serum ceruloplasmin
High-Yield Explanation
Wilson disease is an inborn error of metabolism due to toxic accumulation of copper in liver,brain,cornea and other tissues.Serum ceruloplasmin is decreased(<20 mg/dl) and the 24 hour urinary copper excretion is more than 100 micrograms/day.Hepatic copper values usually above 250 micrograms /gram of dry weight of liver. Reference:Essential pediatrics-Ghai,8th edition,page no:321

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