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Pathology General 0909f69e

A 22-year-old man has features of arm span greater than height, subluxated lenses, flattened and dilation of the aortic most likely diagnosis is?

A
Ehlers-Danlos syndrome
B
Werner's syndrome
C
Laurence-Moon-Biedl syndrome
D
Marfan syndrome
High-Yield Explanation
The presentation in the question is of a patient with Marfan syndrome. • Marfan syndrome is caused by a mutation in a single allele of the fibrillin gene (FBN1). • The gene product is a major component of elastin-associated microfibrils. Long, thin extremities; ectopia lentis, and aortic aneurysms are the classical triad. • Mutations in the FBN2 gene can also cause Marfan syndrome, but without aneurysms

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