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Pediatrics Genetics And Genetic Disorders 0899ab83

Which of the following feature is not seen in Prader Willi syndrome?

A
Obesity
B
Mental retardation
C
Ataxia
D
Hypotonia
High-Yield Explanation
Ans. is 'c' i.e., Ataxia Prader willi syndrome* It is due to paternal genomic imprinting in which there is deletion on paternal chromosome 15.* They are characterized by hypotonia, obesity, short stature, mental retardation, hypogonadism, hyperphagia, and short hand and feet.* There is decrease in GnRH, LH, FSH and GH. Ghrelin levels are raised.

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