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Pharmacology General 07c14e46

Vasopressin antagonist acts on which pa of the nephron?

A
Proximal convoluted tubule
B
Distal convoluted tubule
C
Coical collecting tubule
D
Medullary collecting duct
High-Yield Explanation
Answer- D (Medullary collecting duct)'The mechanism by which vasopressin exes its anti-diuretic effect is activated by V2 receptors and involves the inseion of aquaporin-2 into the apical (luminal) membranes at the principle cells of the collecting duct.'

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