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Medicine General 079bded4

PNH patients will be having deficient surface proteins that normally protect the red cells from activated compliments. What are the two deficient surface proteins?

A
CD 45 and CD 59
B
CD 51 and CD 59
C
CD 55 and CD 59
D
CD58 and CD 59
High-Yield Explanation
The definitive diagnosis of PNH is based on the demonstration that a substantial propoion of the patient's red cells have an increased susceptibility to complement (C), due to the deficiency on their surface of proteins (paicularly CD59 and CD55). Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 884

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