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Medicine Wilson Disease 070d9d1b

A 15 year old child presents with falling school grades and development of abnormal posture. On examination dystonia and increase muscle tone is noted. Slit lamp examination shows presence of KF ring. Liver biopsy for copper will be stained by which of the following stain?

A
Perl stain
B
Rubeanic acid
C
Supravital stain
D
Schmorl's method
High-Yield Explanation
Rubeanic acid and Rhodamine stains are utilized to detect the cytoplasmic accumulation of copper in the liver. Schmorl's method is used for detecting melanin and uses the reducing propeies of melanin to stain granules blue-green. It is also used to detect lipofuscin.

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