Which neurotransmitter is responsible for anterograde dilatation of the small intestine?
High-Yield Explanation
VIP is responsible for antergrade dilatation of the small intestine. Cholinergic neurons passing inn antegrade direction produce NO and VIP which cause relaxation of a segment of the intestine in front of the bolus. Cholinergic neurons passing in retrograde direction produce substance P and acetylcholine which cause contraction of a segment of the intestine behind the bolus. Ref: Ganong&;s Review of Medical Physiology 26th edition Pgno: 485