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Microbiology Human Immunodeficiency Virus 06d1fb6e

Regarding HIV infection, not true is:

A
p24 is used for early diagnosis
B
Lysis of infected CD4 cells is seen
C
Dendritic cells do not support replication
D
Macrophage is a reservoir for the virus
High-Yield Explanation
Ans. is 'c' i.e., Dendritic cells do not support replication(Ref: Ananthanarayan, 9th/e, p. 574, 577 and 8th/e, p. 573; Harrison, 18th/e, p. 1531; 17th/e, p. 1159; Harrison, 16th ed., p. 1095)* Follicular dendritic cells from tonsil can be infected by HIV without the involvement of CD4.* Dendritic cells play an important role in the initiation of HIV infection.* "Complexes of infected CD4+T Cells and dendritic cells provide an optimal microenvironment for virus replication."

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