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Pharmacology Adrenergic System 068c32fa

The rate limiting step for norepinephrine synthesis is:

A
Conversion of phenylalanine to tyrosine
B
Conversion of tyrosine to DOPA
C
Conversion of DOPA to dopamine
D
Conversion of dopamine to norepinephrine
High-Yield Explanation
Ans. (B) Conversion of tyrosine to DOPA(Ref: Katzung 10/e p78; KDT 8th/e p136)Rate limiting enzyme in norepinephrine synthesis is tyrosine hydroxylase that catalyses the conversion of tyrosine to dopa. In ACh synthesis, rate limiting step is uptake of choline by the neurons.

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