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Pathology Chronic Myelogenous Leukemia 0689c1a0

Which of the following is not true about chronic myelogenous leukemia?

A
BCR-ABL fusion is involved in the oncogenesis
B
Pseudo Gaucher cells may be present in the bone marrow examination
C
Blast crisis in the disease may have lymphoblasts
D
BM biopsy is essential for confirmation of diagnosis
High-Yield Explanation
Option A - It is d/t chromosomal translocation t Philadelphia chromosome Option B - Pseudo Gaucher cells are seen in patient with CML . Gaucher cells are seen in Gaucher disease Option C - CML- is an example of triphasic leukemia. Patient in blast phase will have both lymphoblasts as well as myeloblast. Option D - For diagnosis of CML there should be presence of Philadelphia chromosome. Technique Used for confirmation is (IOC)- Fluorescent in Situ Hybridization. FISH - Used colored probe dyes for a paicular gene.

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