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Pathology Chemical Mediators and Regulators of Inflammation 065f5692

Pro inflammatory Cytokines include all of the following except -

A
Interleukin 1
B
Interleukin-10
C
Interleukin6
D
TNF-Alpha
High-Yield Explanation
Ans. is 'b' i.e., Interleukin-10 o Cytokines are involved in immunological reaction, but some cytokines may also take part in inflammation.o They may be: -1. Proinflammatorv cytokineso Involved in amplification of inflammation and tissue destruction.o IL-1 & TNF-a are the two most important proinflammatorv cytokines. IL-6 may also act as proinflammatorv cytokine.o Other proinflammatory cytokines are IL-2, IL-4, IL-5, IL-6, IL-8, IL-I1, IL-12, IL-15, IL-21, IL-23, IFN- gamma and granulocyte- macrophage- colony stimulatinhg factor (GM-CSF). ( Source Fundamental immunology by William E. Paul).2 Antinflammatory cytokineso Reduce inflammation and produce healing,o Example are IL-4, IL-13, IL-1L-10

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