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Medicine General 065b0aa4

Which is most likely to be increased in Vit K deficiency:

A
P.T.T.
B
P.T.
C
Platelet count
D
Fibrinogen time
High-Yield Explanation
Answer is B (P.T.): Although PT and PTT both will he affected PT is the single best answer as explained below. Therefore both intrinsic & extrinsic mechanisms of the coagulation cascade are affected. (Refer previous questions) PT & PTT both will be prolonged. However, factor VII has sho t1/2 & so PT is the first to be prolonged (even in mild vit. K deficiency) Later, factors II, IX & X will also fall, causing PTT to be prolonged. PT is thus the better choice out of PT and PTT

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