Which of the following statements is TRUE regarding termination of action of a drug?
High-Yield Explanation
* Action of a drug can be terminated either by hepatic metabolism or by renal excretion. Other pathways like excretion in sweat or saliva plays minor roles. * Most of the drugs are inactivated by metabolism. However, some drugs may be activated from inactive form (prodrugs) and others may produce active metabolites. * Some drugs may act away from blood e.g. digoxin leaves bloodstream and enters the hea to produce its action.