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General Medicine General 05dc249d

Examination of a skin lesion demonstrates very abnormal squamous cells with a high nuclear/cytoplasmic ratio and clumped chromatin. These cells form nests within the epidermis that extend to the superficial surface of the epithelium. In some places, nests of these cells have central areas of abnormal keratin formation. The basement membrane is intact and no nests of cells are seen in the dermis. Which of the following terms best describes this lesion?

A
Carcinoma in situ
B
Dysplasia
C
Invasive carcinoma
D
Metaplasia

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