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Biochemistry Miscellaneous (Bio-Chemistry) 05cce392

FALSE about Cvtochrome-P450

A
It is exclusively seen in ER of cells of liver and intestines
B
Peroxidase converts H2O2 at the expense of electron acceptors
C
Catalase use H2O2 as both electron acceptor and donor
D
Superoxide ion is CL most toxic form
High-Yield Explanation
(B) Peroxidase converts H202 at the expense of electron acceptors # Cytochrome-P450 are located on the smooth endoplasmic reticulum of cells throughout the body, but the highest concentrations are found in the liver (hepatocytes) and small intestine> Catalase is a hemoprotein containing four heme groups. In addition to possessing peroxidase activity, it is able to use one molecule of H2O2 as a substrate electron donor and another molecule of H202 as an oxidant or electron acceptor> Transfer of a single electron to 02 generates the potentially damaging superoxide anion free radical (02"-), the destructive effects of which are amplified by its giving rise to free radical chain reactions.

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