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Medicine Kidney 05bc1163

Which of the following is not a characteristic of Fanconi's anemia ?

A
Hematologic abnormalities in infancy
B
Pancytopenia
C
Skeletal anomalies
D
Chromosome fragility
High-Yield Explanation
FANCONI ANEMIA- Autosomal recessive disorder manifests as congenital developmental anomalies ,progressive pancytopenia ,increased risk of malignancy. Chromosomes are susceptible to DNA cross linking agents Patients have sho stature, cafe au lait spots, and anomalies involving thumb radius and genitourinary tract . Ref:Harrison 20 th edition pg no 725

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