Limited cutaneous systemic sclerosis have the following characteristic autoantibody positivity:

Subset of systemic sclerosis limited cutaneous scleroderma has the following features: Skin involvement-Indolent onset and progression. Limited to fingers. Raynaud's phenomenon-Precedes skin involvement; associated with critical ischemia Pulmonary aery hypeension-Frequent, late, may be isolated Pulmonary fibrosis - rare scleroderma renal crisis-Very rare Calcinosis cutis-Frequent, prominent Characteristic autoantibodies-Anti Centromere In Diffuse systemic sclerosis Characteristic autoantibodies-Anti Topoisomerase I (Scl-70), anti-RNA polymerase III Ref: Harrison, E-18, P- 2758.