Antigen-antibody binding occurs at

General features of the antigen-antibody reaction The reaction is specific, an antigen combines with only its homologous antibody and vice versa, the specificity however is not absolute. Antigen-Antibody reaction requires the presence of electrolytes at a specific pH and temperature Bonds involved in Antigen-Antibody reaction are - Van der Waal's bond, Ionic bonds, and Hydrogen bonding Covalent bonds are not involved There is no denaturation of the antigen or antibody during the reaction Entire molecule of the antigen and antibody reacts The combination occurs at the surface. Therefore it is surface antigens that are immunologically relevant The combination is firm and reversible Both antigen and antibody participate in the formation of agglutinates or precipitates.