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Pathology Esophageal disorders 03f2e145

A 65-year-old woman who is a known case of Hashimoto's thyroiditis presented with symptoms of malabsorption. After evaluation, she was diagnosed to have atrophic gastritis. Which of the following is not feature of this patient's condition?

A
Anti-parietal cell antibodies
B
Excessive acid production in the stomach
C
Endocrine cell hyperplasia
D
Vitamin B12 deficiency
High-Yield Explanation
Autoimmune atrophic gastritis is characterized by: Antibodies to parietal cells and intrinsic factor that can be detected in serum and gastric secretions Reduced serum pepsinogen I concentration Endocrine cell hyperplasia Vitamin B12 deficiency Defective gastric acid secretion (achlorhydria) Pernicious anemia and autoimmune atrophic gastritis are often associated with other autoimmune diseases including Hashimoto thyroiditis, type 1 diabetes mellitus, Addison disease Clinical features are mainly related to vitamin B12 deficiency, including megaloblastic anemia, atrophic glossitis, epithelial megaloblastosis, malabsorptive diarrhea.

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